TRX - 1 Regulates SKN - 1 Nuclear Localization Cell Non - Autonomously in Caenorhabditis 1 elegans 2 3
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چکیده
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis 1 elegans 2 3 Katie C. McCallum, Bin Liu, Juan Carlos Fierro-González, Peter Swoboda, Swathi Arur, 4 Antonio Miranda-Vizuete, Danielle A. Garsin 5 6 Department of Microbiology and Molecular Genetics, The University of Texas Health Science 7 Center at Houston, Houston, Texas 77030. 8 The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 9 77030 10 Department of Genetics, UT MD Anderson Cancer Center, Houston, Texas, 77030 11 Center for Genetics and Genomics, Department of Genetics, UT MD Anderson Cancer Center, 12 Houston, Texas, 77030 13 Department of Biosciences and Nutrition at Novum, Karolinska Institute, S-141 83 Huddinge, 14 Sweden. 15 Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad 16 de Sevilla, E-41013 Sevilla, Spain 17 Equal senior author contribution 18 19 20 21 22 23 24 25 26 Genetics: Early Online, published on February 26, 2016 as 10.1534/genetics.115.185272
منابع مشابه
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their importance. Here, we add a thioredoxin, encoded by trx-1, to the expansive list of SKN-1 regulato...
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The transcription factor SKN-1 protects Caenorhabditis elegans from stress and promotes longevity. SKN-1 is regulated by diverse signals that control metabolism, development, and stress responses, but the mechanisms of regulation and signal integration are unknown. We screened the C. elegans genome for regulators of cytoprotective gene expression and identified a new SKN-1 regulatory pathway. S...
متن کاملThe C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
The evolutionarily conserved p38 mitogen-activated protein kinase (MAPK) cascade is an integral part of the response to a variety of environmental stresses. Here we show that the Caenorhabditis elegans PMK-1 p38 MAPK pathway regulates the oxidative stress response via the CNC transcription factor SKN-1. In response to oxidative stress, PMK-1 phosphorylates SKN-1, leading to its accumulation in ...
متن کاملDirect interaction between the WD40 repeat protein WDR-23 and SKN-1/Nrf inhibits binding to target DNA.
SKN-1/Nrf transcription factors activate cytoprotective genes in response to reactive small molecules and strongly influence stress resistance, longevity, and development. The molecular mechanisms of SKN-1/Nrf regulation are poorly defined. We previously identified the WD40 repeat protein WDR-23 as a repressor of Caenorhabditis elegans SKN-1 that functions with a ubiquitin ligase to presumably ...
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Identification of biologically active natural compounds that promote health and longevity, and understanding how they act, will provide insights into aging and metabolism, and strategies for developing agents that prevent chronic disease. The garlic-derived thioallyl compounds S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC) have been shown to have multiple biological activities. Here w...
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